Research Scientist in Protein Production

蛋白質生產是生物藥物開發的重要基礎，直接影響新藥研發的速度與品質。本職務將負責從 高通量 (HTP) 蛋白質表現 到 公升級 (L-scale) 生產 的流程，快速提供高品質蛋白質作為 藥物可開發性評估 的關鍵物料。特別適合具有分子生物學背景，並對載體設計（尤其是複雜分子如 雙特異性抗體）有興趣的人才。加入我們團隊後，您不僅能在蛋白質生產專案中發揮專長，還能接觸細胞株建立及跨部門合作，參與推動新穎製程平台的研發。

  1. Mammalian Cell Line Cultivation and Protein Production -Responsible for cultivation, passaging, and scale-up of mammalian cell lines (CHO, HEK293, etc.). -Support high-throughput (HTP) protein expression workflows through to liter-scale production to ensure rapid delivery of critical drug development materials.

  2. Molecular Cloning and Vector Design

  • Apply strong molecular biology expertise in cloning, vector construction, and expression system optimization.
  • Engage in vector design for complex molecules, including bi-specific antibodies and other recombinant proteins.
  1. Bi-specific Antibody and Complex Molecule Expression
  • Express and evaluate bi-specific antibodies and complex recombinant proteins, focusing on yield, stability, and suitability for drug developability studies.

  1. Exposure to Cell Line Generation While not the primary focus, candidates will gain exposure to stable cell line generation and learn related techniques through project participation.

  2. Cross-functional Collaboration

  • Work closely with upstream, downstream, and analytical development teams to support integrated protein production projects.
  • Communicate results effectively through reports and presentations to both internal teams and external clients.
  1. Laboratory and Project Support
  • Assist with laboratory material management and ensure smooth operation of protein production pipelines.
  • Provide technical support across different divisions as needed.